Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.
An epidemic of halloween cookie card Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV.This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent sign